College of Science

In this study, some of five membered and fused heterocyclic derivatives containing 1,2,4- Triazole, 1,3,4- Thiadiazole and triazolo [3,4-b] thiadiazine were synthesized by several cyclization steps.2, 5-dimercapto-1, 3, 4-thiadiazole [A1] was obtained by the reaction of hydrazine hydrate with   carbon disulfide. Compound [A1] was reacted with Ethyl chloro acetate in presence of alkali ethanol to give 2, 5-bis (thioethylacetate 2, 2', diyl)1,3,4 thiadiazole [A2].

1- This work involves preparation of some organic compounds contain hetero-atoms, that starting from (E)-2-benzylidene hydrazine carbothioamide [1] to (E)-5-(2-chloro ethyl thio)-N-(1-phenyl ethylidene)-1,3,4-thiadiazol-2-amine [21], are summarized below:   

- First set of organic compounds was prepared in one step by a condensation reaction between the carbonyl group of aldehydes or ketones and the amino group of Thiosemicarbazide derivatives to produce the compounds:

[1]- (E)-2-benzylidene hydrazine carbothioamide.

Aluminum chloride-urea ionic liquid was investigated by Lewis acid-base titration with chloride ions for its active species concentration with the aide of electronic spectroscopy.