Synthesis ,characterization ,antioxidant and anti-Cancer activity studies of gold (III)complexes with heterocyclic compounds

number: 
3339
English
department: 
Degree: 
Author: 
Ayah Jamal Abdul Hameed
Supervisor: 
Assist. Prof. Dr. Firas Abdullah Hassan
year: 
2014
  • A series of  1,2,4-triazole derivatives were synthesized by cyclization reaction, the benzoic acid hydrazide (1) was synthesized by reaction of methyl benzoate with hydrazine hydrate then  compound (1)  was reacted with CS2 in solution of alkali ethanol to give potassium dithiocarbazinate salt (2) , the basic nucleus 4-amino-5-phenyl-1-4H-1,2,4-triazole -3-thiol (3) was prepared by cyclization of  potassium salt (2)  with hydrazine hydrate using water as solvent under reflux condition . compound (3) was subjected to addition reaction with different  aromatic aldehydes to synthesize Schiff bases (4a,b) which were cyclized by treating with thioglycolic acid to prepare compounds (5a,b).compounds (6) and (7) obtained by cyclization reaction of compound (3) with urea and thiourea .
  • Also in this research, 1,3,4- thiadiazole  derivatives were synthesized by cyclization of thiosemicarbazied with substituted carboxylic acid and sulphuric acid, to yield 2-amino-5-R-1,3,4-thiadiazole (8). Schiff bases formation (9a,b) were by reflux of aromatic aldehyde with 2-amino-5-R-1,3,4-thiadiazole (8) in the presence of  absolute ethanol. Compounds (10a,b) were prepared by cyclization reaction of compounds (9a,b) with thioglycolic acid.
  • The   Synthesized compound were confirmed by their melting point ,FTIR ,U.V-visible ,1HNMR spectra and evaluated for their antioxidant activity by using stable free radical 1,1-diphenyl-2-picryl-hydrazyl DPPH. Of all tested compounds. compound (5b) was the most active in all concentrations  compared to standard Ascorbic acid  with an IC50 value 5.84 μg/ml .